Year Disease Location Notes *1563–1564 Bubonic plague London, England 1563 London plague *1592-1593 Bubonic plauge London, England 1592–93 London plague *1603 Bubonic plague United Kingdom Primarily London 1612 Bubonic plague United Kingdom *1616-1620 Multiple infections Southern New England, especially Wampanoag people Unknown, possibly leptospirosis with Weil syndrome. Classic explanations include yellow fever, bubonic plague, influenza, smallpox, chickenpox, typhus, and syndemic infection
